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Human Reproduction, Vol. 18, No. 9, 1853-1857, September 2003
© 2003 European Society of Human Reproduction and Embryology

Achievement of second parenthood in an ART programme using frozen donor semen: cohort follow-up

F. Guerif, M.H. Saussereau, C. Barthelemy, M. Lanoue, C. Lecomte, V. Ract, J. Lansac and D. Royere1

CECOS, Biologie de la Reproduction, Département de Gynécologie-Obstétrique et Reproduction Humaine, Centre Hospitalier Universitaire Bretonneau, 37044 Tours, France

1 To whom correspondence should be addressed. e-mail: royere{at}med.univ-tours.fr

BACKGROUND: This study was designed to determine the efficacy of a programme using frozen donor semen in a cohort of patients returning for treatment after previously conceiving through donor insemination (DI). METHODS: The cohort included 222 couples with secondary infertility (previous live birth) in one University Hospital Centre. The treatment sequence involved DI cycles until completion. Live births, drop-out for personal or medical reasons and recourse to IVF with donor semen (IVF-D) were recorded for all patients. Live births were expressed as both rate per cycle and crude cumulative rate. RESULTS: At the end of the DI cycles, 65% of couples in the cohort achieved second parenthood. Most of them (77%) succeeded after only four DI cycles. The majority of couples who stopped treatment did so for personal reasons. CONCLUSIONS: Patients involved in a second parenthood project belong to a ‘selected’ population. Management and counselling of such patients need to reconcile the early efficacy of DI cycles, the invasiveness of the IVF-D procedure and the availability of donor semen.

Key words: cohort/crude cumulative live birth rate/donor insemination/frozen donor semen/secondary infertility


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