Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF ) Freely available
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (15)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Binda, M.M.
Right arrow Articles by Koninckx, P.R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Binda, M.M.
Right arrow Articles by Koninckx, P.R.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Human Reproduction, Vol. 18, No. 12, 2503-2507, December 2003
© 2003 European Society of Human Reproduction and Embryology

Reactive oxygen species and adhesion formation

Clinical implications in adhesion prevention

M.M. Binda1,3, C.R. Molinas1,2 and P.R. Koninckx1,2

1 Department of Obstetrics and Gynaecology and 2 Centre for Surgical Technologies, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium

3 To whom correspondence should be addressed at: Department of Obstetrics and Gynaecology, University Hospital Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium. e-mail: MariaMercedes.Binda{at}uz.kuleuven.ac.be

Postoperative adhesion formation is a major clinical problem. It has been demonstrated that the pneumoperitoneum used during laparoscopy is a cofactor in adhesion formation. Reactive oxygen species (ROS) are produced in a hyperoxic environment and during the ischaemia/reperfusion process. ROS activity is deleterious for cells, which protect themselves by an antioxidant system known as ROS scavengers. ROS activity can increase by up-regulation of ROS themselves or by down-regulation of ROS scavengers. Recent data also point to a role for ROS in adhesion formation since the administration of ROS scavengers decreases adhesion formation in several animal models. ROS activity increases during both laparotomy and laparoscopy. During laparoscopy, the pneumoperitoneum determines ischaemia at the time of insuflation and reperfusion at the time of deflation. During laparotomy, the environment has a 150 mmHg partial pressure of oxygen (pO2), which is much higher than the intracellular pO2 (5–40 mmHg). This can explain the increase in ROS activity. The aim of this debate is to open a discussion about the importance of ROS activity, besides the known players and mechanisms involved, in adhesion formation and in adhesion prevention.

Key words: adhesion formation/antioxidants/free radical scavengers/pneumoperitoneum/reactive oxygen species


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Hum Reprod UpdateHome page
C. Nappi, A. Di Spiezio Sardo, E. Greco, M. Guida, S. Bettocchi, and G. Bifulco
Prevention of adhesions in gynaecological endoscopy
Hum. Reprod. Update, July 1, 2007; 13(4): 379 - 394.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
N. Bourdel, S. Matsuzaki, J.-E. Bazin, J.-L. Pouly, G. Mage, and M. Canis
Peritoneal tissue-oxygen tension during a carbon dioxide pneumoperitoneum in a mouse laparoscopic model with controlled respiratory support
Hum. Reprod., April 1, 2007; 22(4): 1149 - 1155.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
C. Stocco, C. Telleria, and G. Gibori
The Molecular Control of Corpus Luteum Formation, Function, and Regression
Endocr. Rev., February 1, 2007; 28(1): 117 - 149.
[Abstract] [Full Text] [PDF]

Home page
 Reproductive SciencesHome page
Z. Alpay, G. M. Saed, and M. P. Diamond
Female Infertility and Free Radicals: Potential Role in Adhesions and Endometriosis
Reproductive Sciences, September 1, 2006; 13(6): 390 - 398.
[Abstract] [PDF]

Home page
 Hum ReprodHome page
M.M. Binda, C.R. Molinas, K. Mailova, and P.R. Koninckx
Effect of temperature upon adhesion formation in a laparoscopic mouse model
Hum. Reprod., November 1, 2004; 19(11): 2626 - 2632.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.