Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF ) Freely available
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (5)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Dale, B.
Right arrow Articles by Izzo, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dale, B.
Right arrow Articles by Izzo, A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Human Reproduction, Vol. 16, No. 7, 1469-1472, July 2001
© 2001 European Society of Human Reproduction and Embryology

Pregnancy after cytoplasmic transfer in a couple suffering from idiopathic infertility: Case report

Brian Dale1,5, Martin Wilding1,2, Giuseppe Botta3, Marianna Rasile4, Marcella Marino1, Loredana Di Matteo1, Giuseppe De Placido2 and Alfredo Izzo4

1 Centre for Reproductive Biology, Clinica Villa Del Sole, Via Manzoni, 15, 80123 Naples, 2 Dipartimento Clinico di Emergenza Ostetrica e Ginecologica e Medicina della Riproduzione, Azienda Universitaria Policlinico, Università degli Studi `Federico II', Via S. Pansini, 5, 80131 Naples, 3 Clinica Ruesch, Via Maria Cristina Di Savoia, 39, 80123 Naples and 4 Istituto di Clinica Ginecologia, II Università di Napoli, Largo Madonna delle Grazie, 80128 Naples, Italy

Couples suffering from idiopathic infertility are among the most difficult to treat in IVF cycles due to the unknown cause of failure to reproduce. This can lead to years of unsuccessful attempts to conceive and often the abandonment of treatment. In some couples, the only observable problem is the development of poor quality embryos. In this case report, we describe the successful use of cytoplasmic donation in a couple where the high level of embryo fragmentation and poor embryo development was thought to be the unique cause of failure to conceive after intracytoplasmic sperm injection (ICSI). We noted a strong reduction in embryo fragmentation and a consequent increase in embryo quality after the treatment. Transfer of four of the embryos receiving donor cytoplasm led to a pregnancy with two gestational sacs and the birth of healthy twins.

Key words: apoptosis/cytoplasmic transfer/IVF/oocyte reconstruction/preimplantation embryo

5 To whom all correspondence should be addressed. E-mail: dale{at}interfree.it


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Hum ReprodHome page
T. Ebner, M. Moser, M. Sommergruber, K. Jesacher, and G. Tews
Complete oocyte activation failure after ICSI can be overcome by a modified injection technique
Hum. Reprod., August 1, 2004; 19(8): 1837 - 1841.
[Abstract] [Full Text] [PDF]

Home page
 Hum Reprod UpdateHome page
R. Levy, K. Elder, and Y. Menezo
Cytoplasmic transfer in oocytes: biochemical aspects
Hum. Reprod. Update, May 1, 2004; 10(3): 241 - 250.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.