Human Reproduction, Vol 12, 368-372, Copyright © 1997 by Oxford University Press
A Mori, YL Zhai, T Toki, T Nikaido and S Fujii
Mast cells (MCs) are widely distributed in most human tissues. Those cells
that contain only tryptase are designated as T-MCs, while those that also
contain chymase are referred to as TC-MCs. This study uses
immunohistochemical staining for tryptase and chymase to assess the
distribution and heterogeneity of these two types of MCs in the human
uterus. The greatest number of MCs was found in the inner (i.e. luminal)
half of the myometrium, with this area containing approximately equal
proportions of T-MCs and TC-MCs. There were fewer MCs in the outer half of
the myometrium and the cervix, but the proportion of TC-MCs in both of
these areas was substantially higher. In contrast, the endometrium
contained significantly fewer MCs, but proportionally more T-MCs. There was
no change in the number of MCs between the proliferative and secretory
phases of the menstrual cycle; however, there was a significantly lower
number in all areas after menopause. Most of the MCs were observed in close
association with uterine smooth muscle cells, as well as in the vicinity of
fibroblasts and collagen, and it appears they may play an important role in
the reconstruction of uterine tissues during the menstrual cycle.
ARTICLES
Distribution and heterogeneity of mast cells in the human uterus
Department of Obstetrics and Gynecology, Shinshu University School of Medicine, Matsumoto, Japan.
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