Skip Navigation

This Article
Right arrow FREE Full Text (PDF ) Freely available
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (11)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Karlsson, C.
Right arrow Articles by Stjernquist, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Karlsson, C.
Right arrow Articles by Stjernquist, M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Human Reproduction, Vol 12, 361-367, Copyright © 1997 by Oxford University Press

ARTICLES

5-Hydroxytryptamine contracts human uterine artery smooth muscle predominantly via 5-HT2 receptors

C Karlsson, G Bodelsson, M Bodelsson and M Stjernquist
Department of Obstetrics & Gynaecology, University Hospital, Malmo, Sweden.

Serotonergic receptors were classified in the isolated human uterine artery with intact endothelium, using agonists and antagonists for 5- hydroxytryptamine (5-HT) receptors. The efficacy for different agonists rated: alpha-methyl-5-HT (5-HT2) = 5-HT (non-selective) = 2-methyl-5-HT (5-HT3) >> sumatriptan (5-HT1), and the potency as: sumatriptan = 5-HT > 5-HT > alpha-methyl-5-HT > 2-methyl-5-HT. The contractile effects of 5-HT and alpha-methyl-5-HT were antagonized by the 5-HT2 receptor antagonist ketanserin and the non-selective antagonist methiothepin. The efficacy of sumatriptan was comparatively low. No interaction was encountered between 2-methyl-5-HT and MDL72222, suggesting an absence of 5-HT3 receptors. The results indicate that the contractile serotonergic receptor population in the human uterine artery mainly comprises 5-HT2 receptors, although a minor contribution of contractile 5-HT1 receptors cannot be excluded.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 HypertensionHome page
S. P. Salas, A. Giacaman, W. Romero, P. Downey, E. Aranda, D. Mezzano, and C. P. Vio
Pregnant Rats Treated With a Serotonin Precursor Have Reduced Fetal Weight and Lower Plasma Volume and Kallikrein Levels
Hypertension, October 1, 2007; 50(4): 773 - 779.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
P. Stralin and S. L. Marklund
Vasoactive factors and growth factors alter vascular smooth muscle cell EC-SOD expression
Am J Physiol Heart Circ Physiol, October 1, 2001; 281(4): H1621 - H1629.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
G. Landstrom, A. Wallin, K. Lundmark, H. Noren, and B. Lindblom
The action of vasoconstrictive agents on human tubal arteries
Hum. Reprod., January 1, 1999; 14(1): 151 - 155.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.