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Human Reproduction, Vol. 6, No. 7, pp. 959-962, 1991
© 1991 European Society of Human Reproduction and Embryology

other

Are there predictive criteria of complicated ovarian hyperstimulation in IVF?

A. Delvigne1, J. Vandromme, B. Lejeune and F. Leroy

IVF Clinic and Human Reproduction Research Unit, Saint Pierre Hospital, Free University of Brussels Belgium

Correspondence: 1To whom correspondence should be addressed

Among 599 trials of in-vitro fertilization (IVF) treatment, complicated ovarian hyperstimulation (OHSS) was diagnosed in 14 cases (2.5%) on the basis of heavy abdominal discomfort and echographic findings (ascites, ovarian enlargement with cysts). Among eight hospitalized patients, four presented with a haemoconcentration and/or electrolytic disturbances. OHSS cases were compared with two control groups for a series of criteria: age, aetiology of infertility, total dose of human menopausal gonadotrophin (HMG), day of oocyte collection, oestradiol (E2 peak level, rate of E2 increase, number of oocytes, number of embryos transferred and embryonic vitality scores. Comparison with a random group of normal IVF trials showed a significant difference for the following parameters: E2 peak level and rate of increase, E2dose of HMG, E2 of egg collection and number of oocytes. When OHSS cases were compared to another control group consisting only of high E2 responders (peak E2 > 2700 pg/ml), no significant difference was found for any of the above-mentioned criteria. In view of this lack of predictive power of individual criteria, stepwise discriminant analysis was applied, showing that this method might provide a predictive mathematical function for evaluating the risk of OHSS before human chononic gonadotrophin (HCG) administration. Such a formula, however, should be validated by a multicentric study in which a greater number of OHSS cases would be tested.

Key words: IVF/complicated ovarian hyperstimulation (OHSS)/oestradiol/peak oestradiol


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