Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF ) Freely available
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (20)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Quenby, S.
Right arrow Articles by Aplin, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Quenby, S.
Right arrow Articles by Aplin, J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Human Reproduction, Vol. 17, No. 8, 1959-1963, August 2002
© 2002 European Society of Human Reproduction and Embryology

OPINION

Recurrent miscarriage: a defect in nature’s quality control?

Siobhan Quenby1, Gill Vince2, Roy Farquharson3 and John Aplin4,5

1 Department of Obstetrics and Gynaecology, 2 Department of Immunology, University of Liverpool, L69 3BX, 3 Liverpool Women’s Hospital, Crown Street, Liverpool L8 7SS and 4 Medical School and School of Biological Sciences, University of Manchester, Research Floor, St Mary’s Hospital, Manchester M13 OJH, UK

Recent data on recurrent miscarriage (RM) is discussed in the framework of the selection failure hypothesis which states, ‘Recurrent miscarriage is the result of failure of the prevention of ‘poor quality’ embryos implanting, allowing embryos that are destined to fail to implant and present clinically as recurrent miscarriage. Thus, recurrent miscarriage is a failure of nature’s quality control.’ The assumption that RM results from the maternal rejection of normal fetuses is challenged and evidence reviewed regarding the contribution of abnormal embryos and endometrial receptivity. Further research is needed to understand the mechanisms of maternal tract–embryo interaction and move towards improved management of recurrent pregnancy loss.

Key words: abnormal pregnancies/embryonic period of gestation/endometrial receptivity/recurrent miscarriage/recurrent pregnancy loss

5 To whom correspondence should be addressed. E-mail: john.aplin{at}man.ac.uk


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 ReproductionHome page
W Zammiti, N Mtiraoui, H Khairi, J-C Gris, W Y Almawi, and T Mahjoub
Associations between tumor necrosis factor-{alpha} and lymphotoxin-{alpha} polymorphisms and idiopathic recurrent miscarriage
Reproduction, March 1, 2008; 135(3): 397 - 403.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
E. Jauniaux, R. G. Farquharson, O. B. Christiansen, N. Exalto, and On behalf of ESHRE Special Interest Group for Earl
Evidence-based guidelines for the investigation and medical treatment of recurrent miscarriage
Hum. Reprod., September 1, 2006; 21(9): 2216 - 2222.
[Abstract] [Full Text] [PDF]

Home page
 Obstet GynecolHome page
K. Bianco, A. B. Caughey, B. L. Shaffer, R. Davis, and M. E. Norton
History of miscarriage and increased incidence of fetal aneuploidy in subsequent pregnancy.
Obstet. Gynecol., May 1, 2006; 107(5): 1098 - 1102.
[Abstract] [Full Text] [PDF]

Home page
 CLIN APPL THROMB HEMOSTHome page
C. J. Glueck, P. Wang, N. Goldenberg, and L. Sieve
Pregnancy Loss, Polycystic Ovary Syndrome, Thrombophilia, Hypofibrinolysis, Enoxaparin, Metformin
Clinical and Applied Thrombosis/Hemostasis, October 1, 2004; 10(4): 323 - 334.
[Abstract] [PDF]

Home page
 Hum ReprodHome page
S. Quenby, R. Farquharson, M. Young, and G. Vince
Successful pregnancy outcome following 19 consecutive miscarriages: Case report
Hum. Reprod., December 1, 2003; 18(12): 2562 - 2564.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
T. Buchholz, P. Lohse, N. Rogenhofer, E. Kosian, R. Pihusch, and C.J. Thaler
Polymorphisms in the ACE and PAI-1 genes are associated with recurrent spontaneous miscarriages
Hum. Reprod., November 1, 2003; 18(11): 2473 - 2477.
[Abstract] [Full Text] [PDF]

Home page
 Obstet GynecolHome page
D. T. Carrell, A. L. Wilcox, L. Lowy, C. M. Peterson, K. P. Jones, L. Erickson, B. Campbell, D. W. Branch, and H. H. Hatasaka
Elevated Sperm Chromosome Aneuploidy and Apoptosis in Patients With Unexplained Recurrent Pregnancy Loss
Obstet. Gynecol., June 1, 2003; 101(6): 1229 - 1235.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.