Human Reproduction, Vol. 16, No. 7, 1489-1492,
July 2001
© 2001 European Society of Human Reproduction and Embryology
Hysteroscopic resection of submucosal myomas in patients with infertility
1 Service de Gynécologie-Obstétrique, Hôpital Antoine Béclère, 92140 Clamart Cedex, France and 2 Université Paris XI, France and Department of Obstetrics and Gynecology, University of British Columbia, Vancouver BC, Canada
BACKGROUND: Submucosal myomas are associated with infertility, and may be treated by hysteroscopic resection. Improvement of the menstrual pattern after surgery has been examined and compared with pregnancy rate in a group of menorrhagic women with primary (n = 24) and secondary (n = 35) infertility. METHODS: The entire patient group (n = 59) was managed between January 1990 and September 1998. The submucosal myomas were intracavitary (n = 15), intramural class 1 (n = 34) and intramural class 2 (n = 10), and none was multiple submucosal myoma. The mean (± SD) age was 36.6 ± 4.6 years; mean myoma size was 24.5 ± 13.3 mm; mean duration of the procedure was 40 ± 23 min; and mean follow-up was 26 ± 18.8 months. Thirty-five patients had one or more associated infertility factors. RESULTS: An improvement in clinical symptoms was observed in 62% of patients. Sixteen patients (27%) conceived, and of these only six (10%) delivered at term. The pregnancy rate was significantly better when myoma was the exclusive aetiology of infertility (41.6%), and when the lesion was 
50 mm in size (57.1%). CONCLUSIONS: Hysteroscopic myomectomy appears safe, and is effective in the control of menstrual disorders. However, the effect on infertility seems limited, particularly in terms of delivery rate. The advanced age of the patients may partly explain these results.
Key words: hysteroscopy/infertility/myomectomy/pregnancy rate/submucosal myomas
3 To whom correspondence should be addressed at: Service de Gynécologie-Obstétrique, Hôpital Antoine Béclère, 157, Rue de la Porte de Trivaux, 92140 Clamart Cedex, France. E-mail: herve.fernandez{at}abc.ap-hop-paris.fr
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