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Human Reproduction, Vol. 15, No. 4, 785-789, April 2000
© 2000 European Society of Human Reproduction and Embryology

Increased risk of non-insulin dependent diabetes mellitus, arterial hypertension and coronary artery disease in perimenopausal women with a history of the polycystic ovary syndrome

D. Cibula1,5, R. Cífková2, M. Fanta1, R. Poledne4, J. Zivny1 and J. Skibová3

1 Department of Obstetrics and Gynecology, General Teaching Hospital, Charles University, Apolinarska 18, Prague 2, 120 00, 2 Department of Preventive Cardiology, 3 Department of Statistics and 4 Laboratory for Atherosclerosis Research, Institute for Clinical and Experimental Medicine, Videnska 1958/9, Prague 4, 140 21, Czech Republic

The aim of the study was to determine the prevalence of non-insulin dependent diabetes mellitus (NIDDM), arterial hypertension, coronary artery disease and the risk factors for these diseases in perimenopausal women with a history of polycystic ovary syndrome (PCOS) treatment. A group of 28 women was selected from a large group of patients who had undergone wedge ovarian resection. A total of 752 controls was selected by age (45–59 years) from a random female population sample. There was no difference between the two groups in body mass index, waist circumference or waist–hip ratio. Both groups were found to have identical family histories of NIDDM, hypertension, and coronary artery disease and identical smoking habits. We did not find a difference between the mean concentrations of lipids and fasting glucose. The two groups did not differ in the proportions of women with elevated lipid concentrations. The prevalence of NIDDM and coronary artery disease was significantly higher in PCOS women. In conclusion, women in the general population have the same level of risk factors at perimenopausal age as PCOS women. Patients with markedly expressed clinical symptoms of PCOS made up a subgroup in the general population at high risk for developing NIDDM and coronary artery disease.

Key words: coronary artery disease/late risks/NIDDM/PCOS

5 To whom correspondence should be addressed


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