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Human Reproduction, Vol. 14, No. 11, 2731-2734, November 1999
© 1999 European Society of Human Reproduction and Embryology

The idiopathic forms of premature menopause and early menopause show the same genetic pattern

M.G. Tibiletti1, G. Testa2, W. Vegetti3,5, F. Alagna3, M. Taborelli1, L. Dalprà4, P.F. Bolis2 and P.G. Crosignani3

1 Department of Clinical and Biological Sciences, University of Insubria, Ospedale di Circolo, V.le Borri 57, 20121 Varese, 2 Obstetrics and Gynaecology Unit, Department of Clinical and Biological Sciences, University of Insubria, V.le Borri 57, 20121 Varese, 3 First Department of Obstetrics and Gynaecology, University of Milan, Via della Commenda 12, 20122 Milan and 4 Department of Biology and Genetics for Medical Sciences, University of Milan, Via Viotti 3/5, 20133 Milan, Italy

Genetic factors may influence the timing of menopause. Premature ovarian failure (POF) has recently been identified as a genetic entity, but no genetic data are available on early menopause (EM). We investigated 36 patients with EM (age of menopause between 40 and 45 years of age) using cytogenetic and pedigree analysis. In 30 patients of this study the EM was idiopathic and 15 subjects (50%) had a familial condition of EM or POF. Pedigree analysis revealed a dominant pattern of inheritance of EM through maternal or paternal relatives. Our data reveal that POF and EM patients show the same genetic features and we postulate that these conditions may be a variable expression of the same genetic disease.

Key words: early menopause/familiarity/genetics

5 To whom correspondence should be addressed


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