Human Reproduction, Vol 13, 3032-3038, Copyright © 1998 by Oxford University Press
DR Kostiner, PJ Turek and RA Reijo
The long arm of the human Y chromosome is required for male fertility.
Deletions in three different regions can cause severe spermatogenic defects
ranging from non-obstructive azoospermia to oligozoospermia. Use of
intracytoplasmic sperm injection (ICSI) may allow Y chromosome defects to
be passed from father to son. Thus, numerous reports have stressed the need
to offer genetic testing to infertile men who select ICSI and a number of
reproductive clinics have begun to do so. The primary objectives of this
review were: firstly, to discuss the characteristics of the published set
of polymerase chain reaction markers and how these characteristics affect
interpretation of Y chromosome deletion analysis and secondly, to summarize
the recent literature pertaining to the genes on the Y chromosome.
REVIEWS
Male infertility: analysis of the markers and genes on the human Y chromosome
Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco 94143-0720, USA.
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