Human Reproduction, Vol 12, 755-758, Copyright © 1997 by Oxford University Press
A Botchan, R Hauser, L Yogev, R Gamzu, G Paz, JB Lessing and H Yavetz
We retrospectively analysed the characteristics of 54 men with testicular
cancer. The group comprised 32 men with pure seminoma and 22 with
non-seminoma germ cell tumours (NSGCT). This group was further compared to
190 healthy sperm donor candidates. Sperm quality was found to be higher in
the seminoma versus the NSGCT patients in: sperm concentration [50 (0-230)
versus 17 (0-288) x 10(6)/ml, P < 0.001], total motile sperm counts
(TMC) [57 (0-508) versus 12 (0-854) x 10(6)/ejaculate, P = 0.002],
post-thaw forward motile concentration [3 (0-28) versus 1.7 (0-17) x
10(6)/ml, P = 0.003] and motility percentage [20 (0-57) versus 12.5 (0-42)
%, P = 0.002]. Serum hormone concentrations did not differ between these
two sub-groups, although the follicle stimulating hormone concentrations
were higher than normal in both (14.6 +/- 2.5 versus 10.4 +/- 1.4 mIU/ml, P
> 0.05). As is well documented, cancer patients were found to have lower
sperm quality compared to healthy candidates. The existence of these
differences, and the fact that testicular cancer affects spermatogenesis,
indicated that the mechanisms involved in the deterioration of sperm
quality can, at least partially, be attributed to the type and origin of
the malignant cancer. The higher sperm counts in the seminoma group may be
related to the fact that the resemblance of the seminoma cells to normal
germ cells is greater than that of the NSGCT cells, and therefore they
retain a better capacity to function. Due to modern assisted reproductive
technologies and micromanipulation achievements, the lower yield of
spermatozoa in severe cases is no longer a major obstacle to offering
cryopreservation to these patients.
ARTICLES
Testicular cancer and spermatogenesis
The Institute for the Study of Fertility, Serlin Maternity Hospital, Sackler Faculty of Medicine, Tel Aviv University, Israel.
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