Human Reproduction, Vol 12, 214-219, Copyright © 1997 by Oxford University Press
A Parra, J Barron, J Sinibaldi, I Coria and A Espinosa de los Monteros
To investigate if an association exists in parous women between
metoclopramide-induced prolactin (PRL) release and chronological age at
first full-term pregnancy and to compare their response to a group of
non-parous women, we studied 139 healthy, non-lactating women, aged
15.8-48.2 years, on days 18-22 of their menstrual cycle (except two
post-menopausal women). There were 61 parous women divided according to
chronological age at first full-term pregnancy: 22 were aged < or = 20.0
years, 25 were aged 20.1-29.9 years and 14 were aged > 30 years. There
were also 50 nulliparous women and 28 women who had experienced only first
trimester abortions. Three basal blood samples were obtained before oral
metoclopramide (10 mg) was administered; subsequently samples were taken at
60, 90 and 120 min. Duplicate serum PRL determinations were performed by
radioimmunoanalysis and the area under the curve (AUC) calculated. In
parous women, the PRL AUC was positively correlated with chronological age
at first full-term pregnancy (P < 0.0001), and it was lower than in
nulliparous women or in women with abortions. These data suggest that in
parous women a greater dopaminergic tone may exist compared with non-parous
women, which seems to decrease gradually as chronological age at first
full-term pregnancy increases.
ARTICLES
Differences in the metoclopramide-induced prolactin release related to age at first full-term pregnancy or nulliparity
Department of Endocrinology, Instituto Nacional de Perinatologia, Mexico City, Mexico.
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